Sabtu, 20 September 2014

Ebook Download

Ebook Download

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Ebook Download

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Product details

File Size: 2968 KB

Print Length: 638 pages

Publisher: Academic Press; 1 edition (October 25, 2011)

Publication Date: October 25, 2011

Sold by: Amazon Digital Services LLC

Language: English

ASIN: B006CFZSEU

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Amazon Best Sellers Rank:

#1,668,937 Paid in Kindle Store (See Top 100 Paid in Kindle Store)

Hi,I have received my book. I will recommend this book to anyone who just enters clinical trial industry. Thank you!

The following is a quotation from a review that was published in Journal of Clinical Research Best Practices, Vol. 8, Sept. 2012. The author of this review is Norman M. Goldfarb.The published review is as follows, and I quote:"Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines, is a solid guide to designing clinical trials for medical scientists, especially those working in oncology, immune disease, and infectious disease. The statistical chapters are brief and include very few formulae. Three chapters address quality-of-life topics. In addition to the core material, the book also includes chapters on some ancillary topics like patents and package inserts."[My comment on the above writing is that the chapter on STATISTICS contains seventeen (17) mathematical formulas.]The published review by Dr. Goldfarb also states, "Essential reading for clinical research professionals."The published review also reveals this:"The section on study designs discusses and provides diagrams for 17 schemas. The following text illustrates the book's fairly technical style:FORWARDS SEQUENCE AND REVERSE SEQUENCE -- THE PUHALLA SCHEMA.The clinical trial of Puhalla et al. (38) contains two arms (Fig. 2.8). Subjects in the first arm received drugs in this order: D followed by AC. In detail, subjects received docetaxel on the first day of each cycle, for 4 cycles, where each cycle was 14 days long. This was followed by doxorubicin (an anthracycline drug) plus cyclophosphamide, on the first day of each cycle, for 4 cycles. Each cycle was 2 weeks long.Now, this is about the second arm. Subjects in the second arm received drugs in the reverse order, that is, AC followed by D. The investigators chose a 2-arm study design, where each arm was the reverse of the other, because it was not possible to predict which order would provide the better outcome.The type of trial design, where one arm uses a "forward sequence" of two drugs, and where another arm uses the "reverse sequence" of the two drugs, sometimes finds a basis in the mechanism of action of certain drugs. The following specifically concerns chemotherapy involving paclitaxel and gemcitabine. As explained by Paccagnella et al. (39) for a clinical trial on lung cancer, "[s]everal reports have shown that the sequence of administration of gemcitabine and paclitaxel may also affect the efficacy of this combination chemotherapy, since paclitaxel increases the concentration of active metabolite of gemcitabine (dFdCTP) when administered first."To repeat, the above review was written by Norman M. Goldfarb. The complete version of Dr. Goldfarb's review was published in J. Clin. Res. Best Practices, Vol. 8, Sept. 2012.

This is the most comprehensive book on clinical trials I've seen so far.Touches all key areas of clinical trials conduct; I very much enjoyed (yes, I do enjoy learning about the work I love!) the elaboration on Biomarkers and Endpoints. This manual is useful even for experienced professionals, has chapters to be used as a reference and presents new information as well. Extremely well organized, easy to read and informative, a must for any clinical research professional.

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